BDBM50079900 7-Nitro-3-trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline::7-nitro-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline::CHEMBL112351

SMILES [O-][N+](=O)c1ccc2CC(NCc2c1)C(F)(F)F

InChI Key InChIKey=AZEWYBRFBDWZGW-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50079900   

TargetPhenylethanolamine N-methyltransferase(Bos taurus (bovine))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50079900(7-Nitro-3-trifluoromethyl-1,2,3,4-tetrahydro-isoqu...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of PNMT (Phenylethanolamine N-Methyltransferase) in vitro More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50079900(7-Nitro-3-trifluoromethyl-1,2,3,4-tetrahydro-isoqu...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibitory activity against human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50079900(7-Nitro-3-trifluoromethyl-1,2,3,4-tetrahydro-isoqu...)
Affinity DataKi:  3.40E+3nMAssay Description:Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]-RX-821002 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Bos taurus (bovine))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50079900(7-Nitro-3-trifluoromethyl-1,2,3,4-tetrahydro-isoqu...)
Affinity DataKi:  1.35E+5nMAssay Description:Inhibitory activity against bovine adrenal phenylethanolamine N-methyl-transferase (PNMT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079900(7-Nitro-3-trifluoromethyl-1,2,3,4-tetrahydro-isoqu...)
Affinity DataKi:  1.50E+6nMAssay Description:Inhibition of [3H]clonidine binding to the rat alpha-2-adrenoceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed