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BDBM50080106 5,5-Bis-(4-bromo-phenyl)-3-(3-hydroxy-propyl)-imidazolidine-2,4-dione::CHEMBL45730

SMILES: OCCCN1C(=O)NC(C1=O)(c1ccc(Br)cc1)c1ccc(Br)cc1

InChI Key: InChIKey=RCWSXVLXYQOHTN-UHFFFAOYSA-N

Data: 2 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50080106   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50080106
PNG
(5,5-Bis-(4-bromo-phenyl)-3-(3-hydroxy-propyl)-imid...)
Show SMILES OCCCN1C(=O)NC(C1=O)(c1ccc(Br)cc1)c1ccc(Br)cc1
Show InChI InChI=1S/C18H16Br2N2O3/c19-14-6-2-12(3-7-14)18(13-4-8-15(20)9-5-13)16(24)22(10-1-11-23)17(25)21-18/h2-9,23H,1,10-11H2,(H,21,25)
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PC cid
PC sid
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Similars

Article
PubMed
103n/an/an/an/an/an/an/an/a



Universit£ Catholiqu£ de Louvain

Curated by ChEMBL


Assay Description
Ability to displace [3H]-SR- 141716A binding to CB1 receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 9: 2233-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00353-4
BindingDB Entry DOI: 10.7270/Q2TB17D5
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50080106
PNG
(5,5-Bis-(4-bromo-phenyl)-3-(3-hydroxy-propyl)-imid...)
Show SMILES OCCCN1C(=O)NC(C1=O)(c1ccc(Br)cc1)c1ccc(Br)cc1
Show InChI InChI=1S/C18H16Br2N2O3/c19-14-6-2-12(3-7-14)18(13-4-8-15(20)9-5-13)16(24)22(10-1-11-23)17(25)21-18/h2-9,23H,1,10-11H2,(H,21,25)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
103n/an/an/an/an/an/an/an/a



Universit£ de Lausanne

Curated by ChEMBL


Assay Description
Compound was evaluated for affinity towards human Cannabinoid receptor 1 using [3H]- SR-141716A as radioligand


J Med Chem 45: 1748-56 (2002)


Article DOI: 10.1021/jm010896y
BindingDB Entry DOI: 10.7270/Q2VM4D02
More data for this
Ligand-Target Pair