BDBM50080840 3,6-Bis[3-(azepan-1-yl)propionamido]acridine::3,6-Bis[3-(hexamethyleneimino)piperizinopropionamido)acridine::3-Azepan-1-yl-N-[6-(3-azepan-1-yl-propionylamino)-acridin-3-yl]-propionamide::CHEMBL82008::N,N'-(acridine-3,6-diyl)bis(3-(azepan-1-yl)propanamide)

SMILES c1cc(cc2c1cc3ccc(cc3n2)NC(=O)CCN4CCCCCC4)NC(=O)CCN5CCCCCC5

InChI Key InChIKey=MSWYQCALXGGGBX-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50080840   

TargetTelomerase reverse transcriptase(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50080840(N,N'-(acridine-3,6-diyl)bis(3-(azepan-1-yl)propana...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibitory activity against Telomerase evaluated by TRAP Assay studies.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50080840(N,N'-(acridine-3,6-diyl)bis(3-(azepan-1-yl)propana...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50080840(N,N'-(acridine-3,6-diyl)bis(3-(azepan-1-yl)propana...)
Affinity DataIC50: 3.10E+3nMAssay Description:Ability to inhibit human telomerase in a modified cell-free TRAP assay using extracts from A2780 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50080840(N,N'-(acridine-3,6-diyl)bis(3-(azepan-1-yl)propana...)
Affinity DataIC50: 3.09E+9nMAssay Description:Inhibition of telomerase in Homo sapiens (human) A549 cells after 24 hr by TRAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article