BDBM50081081 6-{4-[2-(4-Quinolin-8-yl-piperazin-1-yl)-ethyl]-phenyl}-pyridin-2-ylamine::CHEMBL87187

SMILES Nc1cccc(n1)-c1ccc(CCN2CCN(CC2)c2cccc3cccnc23)cc1

InChI Key InChIKey=BTEINZDTJWUOFJ-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50081081   

Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50081081(6-{4-[2-(4-Quinolin-8-yl-piperazin-1-yl)-ethyl]-ph...)
Affinity DataKi:  3nMAssay Description:Binding affinity of compound to human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50081081(6-{4-[2-(4-Quinolin-8-yl-piperazin-1-yl)-ethyl]-ph...)
Affinity DataKi:  11nMAssay Description:Binding ability of compound to human Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50081081(6-{4-[2-(4-Quinolin-8-yl-piperazin-1-yl)-ethyl]-ph...)
Affinity DataKi:  14nMAssay Description:Binding affinity of compound to human 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50081081(6-{4-[2-(4-Quinolin-8-yl-piperazin-1-yl)-ethyl]-ph...)
Affinity DataIC50: 130nMAssay Description:Inhibitory activity against rat neuronal nitric oxide synthase (nNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50081081(6-{4-[2-(4-Quinolin-8-yl-piperazin-1-yl)-ethyl]-ph...)
Affinity DataIC50: 212nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50081081(6-{4-[2-(4-Quinolin-8-yl-piperazin-1-yl)-ethyl]-ph...)
Affinity DataIC50: 825nMAssay Description:Inhibitory activity against human endothelial nitric oxide synthase (eNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed