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BDBM50081332 4-(5-Azido-6,7-dimethoxy-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester::CHEMBL338340

SMILES: CCOC(=O)CCCn1cnc2cc(OC)c(OC)c(N=[N+]=[N-])c2c1=O

InChI Key: InChIKey=IPAVQNROYTZLKO-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50081332   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tumor necrosis factor


(Homo sapiens (Human))
BDBM50081332
PNG
(4-(5-Azido-6,7-dimethoxy-4-oxo-4H-quinazolin-3-yl)...)
Show SMILES CCOC(=O)CCCn1cnc2cc(OC)c(OC)c(N=[N+]=[N-])c2c1=O
Show InChI InChI=1S/C16H19N5O5/c1-4-26-12(22)6-5-7-21-9-18-10-8-11(24-2)15(25-3)14(19-20-17)13(10)16(21)23/h8-9H,4-7H2,1-3H3
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MMDB

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Similars

Article
PubMed
n/an/a>2.50E+4n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
The compound was tested in vitro for inhibitory activity against Tumor necrosis factor alpha from human PMBC cell line by ELISA test.


J Med Chem 42: 3860-73 (1999)


Article DOI: 10.1021/jm9805900
BindingDB Entry DOI: 10.7270/Q2TH8NDH
More data for this
Ligand-Target Pair