BDBM50081914 5-(3-Heptyloxy-benzyl)-pyrimidine-2,4-diamine::CHEMBL285209

SMILES CCCCCCCOc1cccc(Cc2cnc(N)nc2N)c1

InChI Key InChIKey=ARHDQCNCQPWFCT-UHFFFAOYSA-N

Data  15 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50081914   

TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081914(5-(3-Heptyloxy-benzyl)-pyrimidine-2,4-diamine | CH...)
Affinity DataKi:  131nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081914(5-(3-Heptyloxy-benzyl)-pyrimidine-2,4-diamine | CH...)
Affinity DataKi:  221nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Leishmania major.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Salmonella enterica subsp. enterica serovar Typhi)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50081914(5-(3-Heptyloxy-benzyl)-pyrimidine-2,4-diamine | CH...)
Affinity DataKi:  407nMAssay Description:Inhibitory activity against Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Uniroyal Chemical

Curated by ChEMBL
LigandPNGBDBM50081914(5-(3-Heptyloxy-benzyl)-pyrimidine-2,4-diamine | CH...)
Affinity DataKi:  407nMAssay Description:Inhibition constant against binding of Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Uniroyal Chemical

Curated by ChEMBL
LigandPNGBDBM50081914(5-(3-Heptyloxy-benzyl)-pyrimidine-2,4-diamine | CH...)
Affinity DataKi:  407nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli (expressed as log 1/Kiapp)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Uniroyal Chemical

Curated by ChEMBL
LigandPNGBDBM50081914(5-(3-Heptyloxy-benzyl)-pyrimidine-2,4-diamine | CH...)
Affinity DataKi:  407nMAssay Description:Apparent inhibitory (log 1/Ki) activity against Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081914(5-(3-Heptyloxy-benzyl)-pyrimidine-2,4-diamine | CH...)
Affinity DataKi:  620nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081914(5-(3-Heptyloxy-benzyl)-pyrimidine-2,4-diamine | CH...)
Affinity DataKi:  1.33E+3nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Trypanosoma cruzi.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50081914(5-(3-Heptyloxy-benzyl)-pyrimidine-2,4-diamine | CH...)
Affinity DataKi:  2.51E+3nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50081914(5-(3-Heptyloxy-benzyl)-pyrimidine-2,4-diamine | CH...)
Affinity DataKi:  2.51E+3nMAssay Description:Inhibition of Rap1A-mediated geranylgeranylation expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
TBA

Curated by ChEMBL
LigandPNGBDBM50081914(5-(3-Heptyloxy-benzyl)-pyrimidine-2,4-diamine | CH...)
Affinity DataKi:  2.69E+3nMpH: 7.2Assay Description:Inhibitory activity against bovine liver Dihydrofolate reductase at pH 7.2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
TBA

Curated by ChEMBL
LigandPNGBDBM50081914(5-(3-Heptyloxy-benzyl)-pyrimidine-2,4-diamine | CH...)
Affinity DataKi:  2.69E+3nMpH: 7.2Assay Description:Inhibitory activity against bovine liver Dihydrofolate reductase at pH 7.2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Gallus gallus (Chicken))
Pomona College

Curated by ChEMBL
LigandPNGBDBM50081914(5-(3-Heptyloxy-benzyl)-pyrimidine-2,4-diamine | CH...)
Affinity DataKi:  1.62E+4nMAssay Description:Inhibitory activity against chicken liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Gallus gallus (Chicken))
Pomona College

Curated by ChEMBL
LigandPNGBDBM50081914(5-(3-Heptyloxy-benzyl)-pyrimidine-2,4-diamine | CH...)
Affinity DataKi:  2.88E+4nMpH: 7.2Assay Description:Inhibitory activity against chicken Dihydrofolate reductase at pH 7.2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Gallus gallus (Chicken))
Pomona College

Curated by ChEMBL
LigandPNGBDBM50081914(5-(3-Heptyloxy-benzyl)-pyrimidine-2,4-diamine | CH...)
Affinity DataKi:  2.88E+4nMpH: 7.2Assay Description:Inhibitory activity against chicken Dihydrofolate reductase at pH 7.2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed