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BDBM50082199 CH3-CH2-COOH::CHEMBL14021::Propionsaeure::acide propanoique::acide propionique::carboxyethane::ethanecarboxylic acid::ethylformic acid::metacetonic acid::methylacetic acid::propanoic acid::propioic acid::propionic acid::propoic acid::pseudoacetic acid

SMILES: CCC(O)=O

InChI Key: InChIKey=XBDQKXXYIPTUBI-UHFFFAOYSA-N

Data: 2 KI  1 IC50  6 EC50

PDB links: 45 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50082199   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Solute carrier family 22 member 20


(Mus musculus)
BDBM50082199
PNG
(CH3-CH2-COOH | CHEMBL14021 | Propionsaeure | acide...)
Show SMILES CCC(O)=O
Show InChI InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)
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PubMed
2.82E+5n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr


J Biol Chem 282: 23841-53 (2007)


Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35
More data for this
Ligand-Target Pair
Solute carrier family 22 member 6


(Mus musculus)
BDBM50082199
PNG
(CH3-CH2-COOH | CHEMBL14021 | Propionsaeure | acide...)
Show SMILES CCC(O)=O
Show InChI InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)
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Article
PubMed
8.18E+6n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr


J Biol Chem 282: 23841-53 (2007)


Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50082199
PNG
(CH3-CH2-COOH | CHEMBL14021 | Propionsaeure | acide...)
Show SMILES CCC(O)=O
Show InChI InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)
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n/an/an/an/a 1.07E+4n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding meas...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Mus musculus)
BDBM50082199
PNG
(CH3-CH2-COOH | CHEMBL14021 | Propionsaeure | acide...)
Show SMILES CCC(O)=O
Show InChI InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)
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Article
PubMed
n/an/an/an/a 2.51E+5n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at FFA2R in mouse mature adipocytes assessed as inhibition of isoproterenol-induced glycerol production


J Med Chem 61: 9534-9550 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00855
BindingDB Entry DOI: 10.7270/Q28S4SFW
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM50082199
PNG
(CH3-CH2-COOH | CHEMBL14021 | Propionsaeure | acide...)
Show SMILES CCC(O)=O
Show InChI InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)
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n/an/an/an/a 2.57E+5n/an/an/an/a



Ogeda SA

Curated by ChEMBL


Assay Description
Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35...


Bioorg Med Chem 26: 5169-5180 (2018)


Article DOI: 10.1016/j.bmc.2018.09.015
BindingDB Entry DOI: 10.7270/Q2RV0R8R
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50082199
PNG
(CH3-CH2-COOH | CHEMBL14021 | Propionsaeure | acide...)
Show SMILES CCC(O)=O
Show InChI InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)
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Article
PubMed
n/an/an/an/a 1.17E+4n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-ind...


J Med Chem 63: 3577-3595 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02036
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM50082199
PNG
(CH3-CH2-COOH | CHEMBL14021 | Propionsaeure | acide...)
Show SMILES CCC(O)=O
Show InChI InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)
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Article
PubMed
n/an/an/an/a 2.50E+5n/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Agonist activity at human GPCR43 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method


J Med Chem 61: 47-61 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00244
BindingDB Entry DOI: 10.7270/Q2JD507R
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM50082199
PNG
(CH3-CH2-COOH | CHEMBL14021 | Propionsaeure | acide...)
Show SMILES CCC(O)=O
Show InChI InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)
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Article
PubMed
n/an/a 1.30E+5n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production


Bioorg Med Chem Lett 20: 493-8 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.112
BindingDB Entry DOI: 10.7270/Q21V5F2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens (Human))
BDBM50082199
PNG
(CH3-CH2-COOH | CHEMBL14021 | Propionsaeure | acide...)
Show SMILES CCC(O)=O
Show InChI InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)
Reactome pathway
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Article
PubMed
n/an/an/an/a 1.20E+4n/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method


J Med Chem 61: 47-61 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00244
BindingDB Entry DOI: 10.7270/Q2JD507R
More data for this
Ligand-Target Pair