BDBM50084437 Batefenterol::GSK961081::GSK961081A::TD-5959

SMILES COc1cc(NC(=O)CCN2CCC(CC2)OC(=O)Nc2ccccc2-c2ccccc2)c(Cl)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12

InChI Key InChIKey=URWYQGVSPQJGGB-DHUJRADRSA-N

Data  1 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50084437   

TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Theravance Biopharma

Curated by ChEMBL
LigandPNGBDBM50084437(Batefenterol | GSK961081 | GSK961081A | TD-5959)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressing CHO-K1 cells incubated for 60 mins or 6 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Theravance Biopharma

Curated by ChEMBL
LigandPNGBDBM50084437(Batefenterol | GSK961081 | GSK961081A | TD-5959)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at human M3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
School Of Pharmaceutical Sciences & The Fifth Affiliated Hospital

Curated by ChEMBL
LigandPNGBDBM50084437(Batefenterol | GSK961081 | GSK961081A | TD-5959)
Affinity DataEC50:  0.251nMAssay Description:Agonist activity at human beta2 adrenoceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
School Of Pharmaceutical Sciences & The Fifth Affiliated Hospital

Curated by ChEMBL
LigandPNGBDBM50084437(Batefenterol | GSK961081 | GSK961081A | TD-5959)
Affinity DataEC50:  0.251nMAssay Description:Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed