BDBM50084621 BMN 673::Talazoparib

SMILES Cn1ncnc1[C@@H]1[C@H](Nc2cc(F)cc3c2c1n[nH]c3=O)c1ccc(F)cc1

InChI Key InChIKey=HWGQMRYQVZSGDQ-HZPDHXFCSA-N

Data  5 KI  15 IC50  10 Kd  2 EC50

PDB links: 5 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50084621   

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataKi:  0.580nMAssay Description:Binding affinity to PARP1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Biomarin Pharmaceutical

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataKi:  0.850nMAssay Description:Inhibition of human PARP2 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysisMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Biomarin Pharmaceutical

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataKi:  0.900nMAssay Description:Inhibition of PARP2 (unknown origin) after 1 min in presence of NAD by top count analysisMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataKi:  1.20nMAssay Description:Inhibition of human PARP1 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysisMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataKi:  1.20nMAssay Description:Inhibition of PARP1 (unknown origin) after 1 min in presence of NAD by top count analysisMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataIC50:  0.570nMAssay Description:Inhibition of PARP1 (unknown origin) after 1 min in presence of NAD by top count analysisMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataIC50:  0.580nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataEC50:  3.20nMAssay Description:Inhibition of human PARP-1 catalytic domain (662 to 1011 residues) expressed in Escherichia coli BL21(DE3) cells incubated for 0.5 hrs by fluorescenc...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataIC50:  1nMAssay Description:Inhibition of N-terminal GST-tagged human full length PARP1 (2 to 1041 residues) expressed in baculovirus infected Sf9 cells using histone mixture (H...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Biomarin Pharmaceutical

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataIC50:  0.600nMAssay Description:Inhibition of N-terminal GST-tagged human PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells using histone mixture (H2A and H2B) a...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataIC50:  0.570nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Biomarin Pharmaceutical

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataIC50:  1nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant N-terminal 6His-6Lys-TEV tagged PARP1 full length expressed in pFastBac expression system incubated for 4 hrs by fluo...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Biomarin Pharmaceutical

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant N-terminal Avi-6His-TEV tagged PARP2 full length expressed in pFastBac expression system incubated for 4 hrs by fluor...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human recombinant PARP5a (E1023 to T1327 amino acids) incubated for 4 hrs by fluorescence anisotropy binding assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataKd:  1.10nMAssay Description:Binding affinity to PARP1 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Biomarin Pharmaceutical

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataKd:  3.30nMAssay Description:Binding affinity to PARP2 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetProtein mono-ADP-ribosyltransferase PARP3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataKd:  24nMAssay Description:Binding affinity to PARP3 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetProtein mono-ADP-ribosyltransferase PARP4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataKd:  0.700nMAssay Description:Binding affinity to PARP4 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataKd:  53nMAssay Description:Binding affinity to PARP5a (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetProtein mono-ADP-ribosyltransferase PARP8(Homo sapiens)
Astrazeneca

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to PARP8 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair

Target InfoNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataKd:  5.70E+3nMAssay Description:Binding affinity to PARP10 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetProtein mono-ADP-ribosyltransferase PARP12(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to PARP12 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetProtein mono-ADP-ribosyltransferase PARP14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to PARP14 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to PARP16 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataIC50:  0.600nMAssay Description:Inhibition of PARP1 (unknown origin) using NAD as substrate incubated for 1 minMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataIC50:  7.20nMAssay Description:Inhibition of PARP1 (unknown origin) by ELISAMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Biomarin Pharmaceutical

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG by cell based assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataEC50:  2.5nMAssay Description:Inhibition of PARP in human LoVo cells assessed as inhibition of poly(ADP)-ribose polymerization for 30 mins by fluorescence assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Biomarin Pharmaceutical

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataIC50:  0.200nMAssay Description:Inhibition of PARP2 (unknown origin) using NAD as substrate incubated for 1 minMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataIC50:  0.600nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL

LigandBDBM50084621(BMN 673 | Talazoparib)Copy SMILESCopy InChI

Affinity DataIC50:  0.570nMAssay Description:Inhibition of human PARP1 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysisMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI