BDBM50084637 2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-carbamoyl)-phenylsulfamoyl]-phenyl ester::2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-carbamoyl)-phenylsulfamoyl]-phenyl ester(ONO-5046)::CHEMBL76688::ONO-5046::Sivelestat

SMILES: CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1C(=O)NCC(O)=O

InChI Key: InChIKey=BTGNGJJLZOIYID-UHFFFAOYSA-N

Data: 4 KI  20 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50084637   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neutrophil elastase (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
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Neutrophil elastase (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
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Prothrombin (Bovine)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Myeloblastin (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
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Cathepsin G (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Neutrophil elastase (Mouse)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	145	n/a	n/a	n/a	n/a	n/a	n/a
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Neutrophil elastase (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
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Myeloblastin (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Cathepsin G (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Kallikrein-1 (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Neutrophil elastase (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	136	n/a	n/a	n/a	n/a	n/a	n/a
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Neutrophil elastase (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.42E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Neutrophil elastase (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Neutrophil elastase (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Neutrophil elastase (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	128	n/a	n/a	n/a	n/a	n/a	n/a
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Neutrophil elastase (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
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Neutrophil elastase (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	704	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Neutrophil elastase (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Neutrophil elastase (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Neutrophil elastase (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
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Neutrophil elastase (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Neutrophil elastase (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		37	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Neutrophil elastase (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neutrophil elastase (Human)	BDBM50084637 (Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...) Show SMILES Show InChI	GoogleScholar	UniChem		200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair