BDBM50085415 3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one::3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one::3-[1-(3,5-Dibromo-4-hydroxy-phenyl)-meth-(Z)-ylidene]-5-iodo-1,3-dihydro-indol-2-one::CHEMBL72365::G6416 (GW5074)::GW-5074

SMILES: Oc1c(Br)cc(\C=C2/C(=O)Nc3ccc(I)cc23)cc1Br

InChI Key: InChIKey=LMXYVLFTZRPNRV-UHFFFAOYSA-N

Data: 24 IC50  4 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50085415   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase B-raf (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PLK4 (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PLK1 (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Microtubule-associated proteins 1A/1B light chain 3B (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	468	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
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Microtubule-associated proteins 1A/1B light chain 3B (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a
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Huntingtin (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C alpha type/glutamine gamma-glutamyltransferase 2 (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Kinesin-like protein KIF15 (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase 20 (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.89E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10.6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase A-Raf (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14.6	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor-interacting serine/threonine-protein kinase 3 (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Dual specificity tyrosine-phosphorylation-regulated kinase 4 (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Casein kinase II subunit alpha (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	279	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	29.3	n/a	n/a	n/a	n/a	n/a	n/a
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Myocilin (Human)	BDBM50085415 (G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.35E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair