BDBM50085910 (Z)-7-{(1R,2R,3R,5S)-2-[(E)-(R)-4-(3-Chloro-phenoxy)-3-hydroxy-but-1-enyl]-3,5-dihydroxy-cyclopentyl}-hept-5-enoic acid::7-{2-[4-(3-Chloro-phenoxy)-3-hydroxy-but-1-enyl]-3,5-dihydroxy-cyclopentyl}-hept-5-enoic acid::CHEMBL37853::CLOPROSTENOL

SMILES c1cc(cc(c1)Cl)OC[C@@H](/C=C/[C@H]2[C@@H](C[C@@H]([C@@H]2C/C=C\CCCC(=O)O)O)O)O

InChI Key InChIKey=VJGGHXVGBSZVMZ-UHFFFAOYSA-N

Data  12 KI  9 IC50  4 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50085910   

TargetProstaglandin F2-alpha receptor(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi:  0.470nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin F2-alpha receptor(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin F2-alpha receptor(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataIC50: 2nMAssay Description:Affinity for human Prostanoid FP receptor expressed in COS-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E2 receptor EP3 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi:  4.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataEC50:  10nMAssay Description:Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin F2-alpha receptor(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi:  31nMAssay Description:Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin F2-alpha receptor(Bovine)
Alcon Laboratories

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi:  31nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Bovine)
Alcon Laboratories

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi:  90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Bovine)
Alcon Laboratories

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi:  91nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataIC50: 496nMAssay Description:Affinity for Prostanoid EP1 receptor expressed in COS-7 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataIC50: 635nMAssay Description:Affinity for Prostanoid EP3 receptor expressed in CHO cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataEC50:  760nMAssay Description:Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP1 (% of control ligand, 17-phi-PGE2=80%)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi:  815nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataEC50:  2.40E+3nMAssay Description:Functional activity in RAT-1cells, transiently-transfected with human TP-receptor (% of control ligand, [3H]-U-46,619=100%)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E2 receptor EP2 subtype(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataIC50: 3.70E+3nMAssay Description:Affinity for Prostanoid EP2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataEC50:  5.00E+3nMAssay Description:Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3(% of control ligand, sulprostone=75%)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSolute carrier organic anion transporter family member 2A1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi:  6.12E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi:  9.14E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Affinity for Prostaglandin I2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Affinity for human Prostaglandin D2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Affinity for Prostanoid EP4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50085910BDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Affinity for Prostanoid TP receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)