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BDBM50089193 4-Fluoro-N-(1,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-benzenesulfonamide::CHEMBL310242

SMILES: CC1(C)[C@H]2CCC(C)(C2)[C@H]1NS(=O)(=O)c1ccc(F)cc1

InChI Key: InChIKey=PBMVETGVYGTZMP-XPFLZZBLSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50089193   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta amyloid A4 protein


(Homo sapiens (human))
BDBM50089193
PNG
(4-Fluoro-N-(1,3,3-trimethyl-bicyclo[2.2.1]hept-2-y...)
Show SMILES CC1(C)[C@H]2CCC(C)(C2)[C@H]1NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C16H22FNO2S/c1-15(2)11-8-9-16(3,10-11)14(15)18-21(19,20)13-6-4-12(17)5-7-13/h4-7,11,14,18H,8-10H2,1-3H3/t11-,14-,16?/m0/s1
PDB
MMDB

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CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of Abeta42 production by inhibiting Gamma-secretase proteolytic pathway in HEK293 cell stably transfected with a double mutant form of hum...


Citation and Details
More data for this
Ligand-Target Pair