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BDBM50089828 4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxy-piperidin-1-yl)-phthalazine-6-carboxylic acid dimethylamide; hydrochloride::CHEMBL553934

SMILES: COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(cc23)C(=O)N(C)C)cc1Cl

InChI Key: InChIKey=UDCMFXADQVNQQM-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50089828   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50089828
PNG
(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxy-pi...)
Show SMILES COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(cc23)C(=O)N(C)C)cc1Cl
Show InChI InChI=1S/C24H28ClN5O3/c1-29(2)24(32)16-5-6-18-19(13-16)22(26-14-15-4-7-21(33-3)20(25)12-15)27-28-23(18)30-10-8-17(31)9-11-30/h4-7,12-13,17,31H,8-11,14H2,1-3H3,(H,26,27)
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Similars

Article
PubMed
n/an/a 5.80E+4n/an/an/an/an/an/a



Eisai Company, Ltd

Curated by ChEMBL


Assay Description
50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets


J Med Chem 43: 2523-9 (2000)


Article DOI: 10.1021/jm9905054
BindingDB Entry DOI: 10.7270/Q2T72J4N
More data for this
Ligand-Target Pair