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BDBM50090641 (2Z,6E)-3-(2,2-dimethylpropyl)-7,11-dimethyldodeca-2,6,10-trien-1-yl (phosphonatooxy)phosphonate::3-substituted farnesyl diphosphate analogue

SMILES: [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6]C([#6])([#6])[#6])=[#6]\[#6]-[#8]P([#8-])(=O)[#8]P([#8-])([#8-])=O

InChI Key: InChIKey=UGDXEILKWUZGPO-JAFZKPNWSA-K

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50090641   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50090641
PNG
((2Z,6E)-3-(2,2-dimethylpropyl)-7,11-dimethyldodeca...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(CC(C)(C)C)=C\COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C19H36O7P2/c1-16(2)9-7-10-17(3)11-8-12-18(15-19(4,5)6)13-14-25-28(23,24)26-27(20,21)22/h9,11,13H,7-8,10,12,14-15H2,1-6H3,(H,23,24)(H2,20,21,22)/p-3/b17-11+,18-13-
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Similars

Article
PubMed
n/an/a 6.60E+3n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirus


Bioorg Med Chem Lett 10: 1763-6 (2000)


Article DOI: 10.1016/s0960-894x(00)00337-1
BindingDB Entry DOI: 10.7270/Q2BZ66KR
More data for this
Ligand-Target Pair