BDBM50091745 (S)-3-({2-[2-(2-Amino-pyridin-4-yl)-ethyl]-3-oxo-2,3-dihydro-1H-isoindole-5-carbonyl}-amino)-pent-4-ynoic acid::CHEMBL59020

SMILES Nc1cc(CCN2Cc3ccc(cc3C2=O)C(=O)N[C@@H](CC(O)=O)C#C)ccn1

InChI Key InChIKey=WZRAHNQCCNXRTD-MRXNPFEDSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50091745   

TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091745((S)-3-({2-[2-(2-Amino-pyridin-4-yl)-ethyl]-3-oxo-2...)
Affinity DataKd:  84nMAssay Description:Competition with [1251]L-692,884 for binding to purified alpha IIb/beta3 integrin, activated by coating onto yttrium silicate scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091745((S)-3-({2-[2-(2-Amino-pyridin-4-yl)-ethyl]-3-oxo-2...)
Affinity DataIC50:  27nMAssay Description:Inhibition of aggregation of human gel-filtered platelets measured by light transmittance method at 37 degrees C.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091745((S)-3-({2-[2-(2-Amino-pyridin-4-yl)-ethyl]-3-oxo-2...)
Affinity DataKd:  2.20nMAssay Description:Inhibition of aggregation of human gel-filtered platelets measured by light transmittance method at 37 degrees C.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed