BDBM50092053 2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihydro-indol-1-yl)-ethanone::CHEMBL69584

SMILES Clc1ccc(CN2CCN(CC(=O)N3CCc4ccccc34)CC2)cc1

InChI Key InChIKey=UHEJJZNLPMHGJA-UHFFFAOYSA-N

Data  8 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50092053   

TargetD(4) dopamine receptor(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50092053(2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihy...)
Affinity DataKi:  1.60nMAssay Description:D4 receptor functional activity was measured inhibition of quinpirole stimulated [35S]GTP-gamma-S binding from cell membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50092053(2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihy...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity towards human Dopamine Receptor D4 was determined via standard competitive displacement assays using [3H]-YM 09151 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50092053(2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihy...)
Affinity DataIC50: 1.60nMAssay Description:Inhibitory concentration against dopamine receptor D4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50092053(2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihy...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity at human Dopamine receptor D4 by [3H]- YM 09151 displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50092053(2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihy...)
Affinity DataIC50: 88nMAssay Description:Inhibitory concentration against alpha adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50092053(2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihy...)
Affinity DataKi:  88nMAssay Description:Binding affinity towards Alpha-1 adrenergic receptor via standard competitive displacement assay using rat brain homogenate with [3H]prazosin as radi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50092053(2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihy...)
Affinity DataKi:  88nMAssay Description:Displacement of [3H]prazosin from alpha-1 adrenergic receptor of rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50092053(2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihy...)
Affinity DataKi:  690nMAssay Description:D2 receptor functional activity was measured through reversal of quinpirole inhibited, forskolin stimulated cAMP production from whole cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50092053(2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihy...)
Affinity DataIC50: 690nMAssay Description:Inhibition constant against dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50092053(2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihy...)
Affinity DataKi:  690nMAssay Description:Binding affinity at human Dopamine receptor D2 by [3H]- YM 09151 displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50092053(2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihy...)
Affinity DataKi:  690nMAssay Description:Binding affinity towards human Dopamine receptor D2 was determined via standard competitive displacement assay using [3H]-YM 09151 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed