BDBM50092683 CHEMBL126366::N,N-Diethyl-4-(isoquinolin-5-yl-piperazin-1-yl-methyl)-benzamide

SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCNCC1)c1cccc2cnccc12

InChI Key InChIKey=WAXHVFCFNPHKLK-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50092683   

TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092683(CHEMBL126366 | N,N-Diethyl-4-(isoquinolin-5-yl-pip...)
Affinity DataEC50:  55nMAssay Description:Agonist potency was measured using GTP gamma-[35S] binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092683(CHEMBL126366 | N,N-Diethyl-4-(isoquinolin-5-yl-pip...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity against cloned human Opioid receptor kappa 1 using [125I]-D-Pro10-dynorphin A[1-11] as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092683(CHEMBL126366 | N,N-Diethyl-4-(isoquinolin-5-yl-pip...)
Affinity DataIC50:  1.48E+3nMAssay Description:Binding affinity against cloned human Opioid receptor mu 1 using [125I]FK33824 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092683(CHEMBL126366 | N,N-Diethyl-4-(isoquinolin-5-yl-pip...)
Affinity DataIC50:  4.10nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed