BDBM50094975 956104-40-8::ARN-509::JNJ-56021927::US10053433, ARN-509::apalutamide

SMILES: CNC(=O)c1ccc(cc1F)N1C(=S)N(C(=O)C11CCC1)c1cnc(C#N)c(c1)C(F)(F)F

InChI Key: InChIKey=HJBWBFZLDZWPHF-UHFFFAOYSA-N

Data: 5 KI  11 IC50  1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50094975   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Androgen receptor (Human)	BDBM50094975 (US10053433, ARN-509 | ARN-509 | JNJ-56021927 | apa...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.95E+4	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein cereblon/CUL4A/AR (Human)	BDBM50094975 (US10053433, ARN-509 | ARN-509 | JNJ-56021927 | apa...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	349	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein cereblon/CUL4A/AR (Human)	BDBM50094975 (US10053433, ARN-509 | ARN-509 | JNJ-56021927 | apa...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.52E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein cereblon/CUL4A/AR (Human)	BDBM50094975 (US10053433, ARN-509 | ARN-509 | JNJ-56021927 | apa...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Androgen receptor (Human)	BDBM50094975 (US10053433, ARN-509 | ARN-509 | JNJ-56021927 | apa...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Androgen receptor (Human)	BDBM50094975 (US10053433, ARN-509 | ARN-509 | JNJ-56021927 | apa...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Androgen receptor (Human)	BDBM50094975 (US10053433, ARN-509 | ARN-509 | JNJ-56021927 | apa...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Androgen receptor (Human)	BDBM50094975 (US10053433, ARN-509 | ARN-509 | JNJ-56021927 | apa...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Androgen receptor (Human)	BDBM50094975 (US10053433, ARN-509 | ARN-509 | JNJ-56021927 | apa...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Androgen receptor (Human)	BDBM50094975 (US10053433, ARN-509 | ARN-509 | JNJ-56021927 | apa...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Androgen receptor (Human)	BDBM50094975 (US10053433, ARN-509 | ARN-509 | JNJ-56021927 | apa...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.11E+3	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Androgen receptor (Human)	BDBM50094975 (US10053433, ARN-509 | ARN-509 | JNJ-56021927 | apa...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.28E+3	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Androgen receptor (Human)	BDBM50094975 (US10053433, ARN-509 | ARN-509 | JNJ-56021927 | apa...) Show SMILES Show InChI	GoogleScholar	UniChem		35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Androgen receptor (Human)	BDBM50094975 (US10053433, ARN-509 | ARN-509 | JNJ-56021927 | apa...) Show SMILES Show InChI	GoogleScholar	UniChem		93	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Androgen receptor (Human)	BDBM50094975 (US10053433, ARN-509 | ARN-509 | JNJ-56021927 | apa...) Show SMILES Show InChI	GoogleScholar	UniChem		1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Androgen receptor (Human)	BDBM50094975 (US10053433, ARN-509 | ARN-509 | JNJ-56021927 | apa...) Show SMILES Show InChI	GoogleScholar	UniChem		1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Androgen receptor (Rat)	BDBM50094975 (US10053433, ARN-509 | ARN-509 | JNJ-56021927 | apa...) Show SMILES Show InChI	GoogleScholar	UniChem		1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair