BDBM50095261 (3-Chloro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine::4-(3'-chloroanilino)-6,7-diethoxyquinazoline hydrochloride::CHEMBL64950

SMILES CCOc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OCC

InChI Key InChIKey=VXCUTOVXETTYDM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50095261   

TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095261((3-Chloro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-a...)
Affinity DataIC50:  1.60E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Sus scrofa (Pig))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095261((3-Chloro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-a...)
Affinity DataIC50:  3.90E+3nMAssay Description:Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095261((3-Chloro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-a...)
Affinity DataIC50:  1.60E+3nMMore data for this Ligand-Target Pair
In DepthDetails
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Lawrence Berkeley National Laboratory

Curated by ChEMBL
LigandPNGBDBM50095261((3-Chloro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-a...)
Affinity DataIC50:  0.380nMAssay Description:Displacement of [125I]4-(3-iodoanilino)-6,7-dimethoxyquinazoline from EGFR tyrosine kinase in human A431 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Lawrence Berkeley National Laboratory

Curated by ChEMBL
LigandPNGBDBM50095261((3-Chloro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-a...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human EGFR tyrosine kinase phosphorylation expressed in mouse BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095261((3-Chloro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-a...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound was evaluated for its concentration required to inhibit the rat liver F16BPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed