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BDBM50095469 (5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol::1-(1-benzyl-3-(5'-hydroxymethyl-2'-furyl)-indazole::CHEMBL333985::[5-(1-Benzyl-1H-indazol-3-yl)-furan-2-yl]-methanol

SMILES: OCc1ccc(o1)-c1nn(Cc2ccccc2)c2ccccc12

InChI Key: InChIKey=OQQVFCKUDYMWGV-UHFFFAOYSA-N

Data: 10 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50095469   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50095469
PNG
((5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol |...)
Show SMILES OCc1ccc(o1)-c1nn(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
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MMDB

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n/an/a 3.19E+4n/an/an/an/an/an/a



Institute of Pharmaceutical Chemistry

Curated by ChEMBL


Assay Description
Inhibition of PDE5 from platelets


J Med Chem 44: 3746-9 (2001)


BindingDB Entry DOI: 10.7270/Q2H13196
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50095469
PNG
((5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol |...)
Show SMILES OCc1ccc(o1)-c1nn(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
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n/an/a 1.38E+4n/an/an/an/an/an/a



Molecular Cancer Research Center

Curated by ChEMBL


Assay Description
Inhibition of hypoxia induced HIF1alpha transcriptional activity in human Hep3B cells by reporter gene assay


Bioorg Med Chem Lett 17: 6305-10 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.005
BindingDB Entry DOI: 10.7270/Q2PR7VQT
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50095469
PNG
((5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol |...)
Show SMILES OCc1ccc(o1)-c1nn(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Molecular Cancer Research Center

Curated by ChEMBL


Assay Description
Inhibition of hypoxia induced HIF1alpha transcriptional activity in human Sk-Hep1 cells by reporter gene assay


Bioorg Med Chem Lett 17: 6305-10 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.005
BindingDB Entry DOI: 10.7270/Q2PR7VQT
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50095469
PNG
((5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol |...)
Show SMILES OCc1ccc(o1)-c1nn(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Molecular Cancer Research Center

Curated by ChEMBL


Assay Description
Inhibition of hypoxia induced HIF1alpha transcriptional activity in human AGS cells by reporter gene assay


Bioorg Med Chem Lett 17: 6305-10 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.005
BindingDB Entry DOI: 10.7270/Q2PR7VQT
More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A


(Homo sapiens (Human))
BDBM50095469
PNG
((5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol |...)
Show SMILES OCc1ccc(o1)-c1nn(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
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n/an/a 2.40E+3n/an/an/an/an/an/a



Tokyo Institute of Innovative Research

Curated by ChEMBL


Assay Description
Inhibition of HIF1alpha transcriptional activity in human HeLa cells transfected with HRE-firefly luciferase and cytomegalovirus-promoter expressing ...


Bioorg Med Chem 28: (2020)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50095469
PNG
((5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol |...)
Show SMILES OCc1ccc(o1)-c1nn(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
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n/an/a 1.50E+3n/an/an/an/an/an/a



Gakushuin University

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...


ACS Med Chem Lett 4: 297-301 (2013)


Article DOI: 10.1021/ml3004632
BindingDB Entry DOI: 10.7270/Q2R212P9
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50095469
PNG
((5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol |...)
Show SMILES OCc1ccc(o1)-c1nn(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
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n/an/a 1.20E+3n/an/an/an/an/an/a



Tokyo Institute of Innovative Research

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1 transcriptional activity in human HeLa cells measured after 12 hrs by luciferase reporter gene assay


Bioorg Med Chem Lett 26: 5887-5890 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.009
BindingDB Entry DOI: 10.7270/Q2X350G6
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50095469
PNG
((5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol |...)
Show SMILES OCc1ccc(o1)-c1nn(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
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n/an/a 4.84E+4n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of HIF1 in human HT1080 cells transfected with 5xHRE/pGL3/VEGF/E1b reporter plasmid pre-incubated for 1 hr followed by incubation under hy...


Bioorg Med Chem 23: 1776-87 (2015)


Article DOI: 10.1016/j.bmc.2015.02.038
BindingDB Entry DOI: 10.7270/Q25M68PX
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50095469
PNG
((5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol |...)
Show SMILES OCc1ccc(o1)-c1nn(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
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n/an/a 1.38E+4n/an/an/an/an/an/a



Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL


Assay Description
Inhibition of hypoxia induced HIF1 transcriptional activity in human Hep3B cells by cell-based HRE reporter assay


J Med Chem 50: 1675-84 (2007)


Article DOI: 10.1021/jm0610292
BindingDB Entry DOI: 10.7270/Q2FT8PSJ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50095469
PNG
((5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol |...)
Show SMILES OCc1ccc(o1)-c1nn(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
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n/an/a 9.21E+3n/an/an/an/an/an/a



Gakushuin University

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha transcriptional activity in HEK293 cells incubated for 16 hrs by hypoxia response element-driven luciferase r...


Bioorg Med Chem Lett 19: 3166-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.122
BindingDB Entry DOI: 10.7270/Q2ZG6SKJ
More data for this
Ligand-Target Pair