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BDBM50095728 6-[5-(4-Ethyl-piperazine-1-sulfonyl)-2-propoxy-phenyl]-1-(3-methoxy-benzyl)-1,7-dihydro-imidazo[4,5-g]quinazolin-8-one::CHEMBL356775

SMILES: CCCOc1ccc(cc1-c1nc2cc3ncn(Cc4cccc(OC)c4)c3cc2c(=O)[nH]1)S(=O)(=O)N1CCN(CC)CC1

InChI Key: InChIKey=MPCOPZZTNXFDBT-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50095728   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50095728
PNG
(6-[5-(4-Ethyl-piperazine-1-sulfonyl)-2-propoxy-phe...)
Show SMILES CCCOc1ccc(cc1-c1nc2cc3ncn(Cc4cccc(OC)c4)c3cc2c(=O)[nH]1)S(=O)(=O)N1CCN(CC)CC1
Show InChI InChI=1S/C32H36N6O5S/c1-4-15-43-30-10-9-24(44(40,41)38-13-11-36(5-2)12-14-38)17-26(30)31-34-27-19-28-29(18-25(27)32(39)35-31)37(21-33-28)20-22-7-6-8-23(16-22)42-3/h6-10,16-19,21H,4-5,11-15,20H2,1-3H3,(H,34,35,39)
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Article
PubMed
n/an/a 1.10n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human platelet Phosphodiesterase 5 was determined


J Med Chem 43: 5037-43 (2001)


Article DOI: 10.1021/jm000336j
BindingDB Entry DOI: 10.7270/Q2862FP8
More data for this
Ligand-Target Pair