BDBM50096331 CHEMBL3577116

SMILES CCn1c2cc(NC)ncc2cc(-c2cc(NC(=O)NCCC(C)(C)C)c(F)cc2C)c1=O

InChI Key InChIKey=RWHKUOWZHDGYHC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50096331   

TargetSerine/threonine-protein kinase B-raf(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50096331(CHEMBL3577116)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of recombinant BRAF V600E mutant (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2016
Entry Details Article
PubMed
LigandPNGBDBM50096331(CHEMBL3577116)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of wild type CRAF (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase coupled assay in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50096331(CHEMBL3577116)
Affinity DataIC50: 11nMAssay Description:Inhibition of wild type BRAF (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase coupled assay in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2016
Entry Details Article
PubMed
LigandPNGBDBM50096331(CHEMBL3577116)
Affinity DataIC50: 25nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50096331(CHEMBL3577116)
Affinity DataIC50: 40nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as inhibition of ERK phosphorylation measured after 72 hrs by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2016
Entry Details Article
PubMed