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BDBM50097895 CHEMBL355071::N-(5-Cyclopropyl-1-phenyl-1H-pyrazole-4-carbonyl)-guanidine

SMILES: NC(=N)NC(=O)c1cnn(c1C1CC1)-c1ccccc1

InChI Key: InChIKey=YZLNQKMWEXOAPY-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50097895   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/hydrogen exchanger 1


(Homo sapiens (Human))
BDBM50097895
PNG
(CHEMBL355071 | N-(5-Cyclopropyl-1-phenyl-1H-pyrazo...)
Show SMILES NC(=N)NC(=O)c1cnn(c1C1CC1)-c1ccccc1
Show InChI InChI=1S/C14H15N5O/c15-14(16)18-13(20)11-8-17-19(12(11)9-6-7-9)10-4-2-1-3-5-10/h1-5,8-9H,6-7H2,(H4,15,16,18,20)
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PC sid
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Similars

Article
PubMed
n/an/a 350n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro concentration required to inhibit NHE-1 mediated intracellular maximal pH recovery by 50%


Bioorg Med Chem Lett 11: 803-7 (2001)


Article DOI: 10.1016/s0960-894x(01)00059-2
BindingDB Entry DOI: 10.7270/Q2TM79CK
More data for this
Ligand-Target Pair
Sodium/hydrogen exchanger 2


(Homo sapiens (Human))
BDBM50097895
PNG
(CHEMBL355071 | N-(5-Cyclopropyl-1-phenyl-1H-pyrazo...)
Show SMILES NC(=N)NC(=O)c1cnn(c1C1CC1)-c1ccccc1
Show InChI InChI=1S/C14H15N5O/c15-14(16)18-13(20)11-8-17-19(12(11)9-6-7-9)10-4-2-1-3-5-10/h1-5,8-9H,6-7H2,(H4,15,16,18,20)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.28E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%


Bioorg Med Chem Lett 11: 803-7 (2001)


Article DOI: 10.1016/s0960-894x(01)00059-2
BindingDB Entry DOI: 10.7270/Q2TM79CK
More data for this
Ligand-Target Pair