BDBM50098002 CHEMBL355551::N-Isopropyl-2-(1-methyl-2-phenyl-1H-indol-3-yl)-N-pyridin-4-ylmethyl-acetamide

SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c(-c2ccccc2)n(C)c2ccccc12

InChI Key InChIKey=LZUIFBUKSHGFTB-UHFFFAOYSA-N

Data  1 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50098002   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098002(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)
Affinity DataIC50:  15nMAssay Description:Concentration required for the inhibitory activity against human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098002(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of K-Ras farnesylation in PSN-1 cells without GGT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098002(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)
Affinity DataEC50:  1.80E+3nMAssay Description:Inhibition of K-Ras farnesylation in PSN-1 cells with 100 nM GGT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098002(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of HDJ-2 farnesylation in PSN-1 cells with 100 nM GGT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098002(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)
Affinity DataEC50:  1.33E+3nMAssay Description:Inhibition of HDJ-2 farnesylation in PSN-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098002(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)
Affinity DataEC50:  1.98E+3nMAssay Description:Inhibition of HDJ-2 farnesylation in PSN-1 cells at without GGT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed