BDBM50098294 6-Methoxy-2-(4'-methoxy-biphenyl-4-sulfonylamino)-hex-4-ynoic acid::CHEMBL274881

SMILES COCC#CCC(NS(=O)(=O)c1ccc(cc1)-c1ccc(OC)cc1)C(O)=O

InChI Key InChIKey=QJKGJGURDPRKGW-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50098294   

TargetStromelysin-1(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098294(6-Methoxy-2-(4'-methoxy-biphenyl-4-sulfonylamino)-...)
Affinity DataIC50:  4.09E+3nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloproteinase-3 (MMP-3) (at pH 7.4)More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098294(6-Methoxy-2-(4'-methoxy-biphenyl-4-sulfonylamino)-...)
Affinity DataIC50:  20nMpH: 7.4Assay Description:Inhibitory activity against matrix metalloproteinase-2 (MMP-2) in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50098294(6-Methoxy-2-(4'-methoxy-biphenyl-4-sulfonylamino)-...)
Affinity DataIC50:  75.9nMAssay Description:Inhibitory activity against recombinant human matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50098294(6-Methoxy-2-(4'-methoxy-biphenyl-4-sulfonylamino)-...)
Affinity DataIC50:  76nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloproteinase-13 in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098294(6-Methoxy-2-(4'-methoxy-biphenyl-4-sulfonylamino)-...)
Affinity DataIC50:  6.15E+3nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloproteinase-1 in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed