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BDBM50098589 E285::SODIUM TETRABORATE::Sodium tetraborate

SMILES: [Na+].[Na+].[O-]B(OB=O)OB([O-])OB=O

InChI Key: InChIKey=RPAYJVFLNVKVRS-UHFFFAOYSA-N

Data: 7 KI

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50098589   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carbonic anhydrase


(Homo sapiens (human))
BDBM50098589
PNG
(E285 | SODIUM TETRABORATE | Sodium tetraborate)
Show SMILES [O-]B(OB=O)OB([O-])OB=O
Show InChI InChI=1S/B4O7.2Na/c5-1-9-3(7)11-4(8)10-2-6;;/q-2;2*+1
PDB
MMDB

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Article
PubMed
6.40E+5n/an/an/an/an/an/an/an/a



Istituto di Bioscienze e Biorisorse (IBBR)-CNR, via P. Castellino 111, 80131 Napoli, Italy.

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method


Bioorg Med Chem Lett 24: 4389-96 (2014)

More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (human))
BDBM50098589
PNG
(E285 | SODIUM TETRABORATE | Sodium tetraborate)
Show SMILES [O-]B(OB=O)OB([O-])OB=O
Show InChI InChI=1S/B4O7.2Na/c5-1-9-3(7)11-4(8)10-2-6;;/q-2;2*+1
PDB
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Article
PubMed
9.50E+5n/an/an/an/an/an/an/an/a



Istituto di Bioscienze e Biorisorse (IBBR)-CNR, via P. Castellino 111, 80131 Napoli, Italy.

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method


Bioorg Med Chem Lett 24: 4389-96 (2014)

More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (human))
BDBM50098589
PNG
(E285 | SODIUM TETRABORATE | Sodium tetraborate)
Show SMILES [O-]B(OB=O)OB([O-])OB=O
Show InChI InChI=1S/B4O7.2Na/c5-1-9-3(7)11-4(8)10-2-6;;/q-2;2*+1
PDB
MMDB

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PubMed
9.50E+5n/an/an/an/an/an/an/an/a



Italy; Universit£ degliStudi di Firenze

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 2 assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method


Citation and Details
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (human))
BDBM50098589
PNG
(E285 | SODIUM TETRABORATE | Sodium tetraborate)
Show SMILES [O-]B(OB=O)OB([O-])OB=O
Show InChI InChI=1S/B4O7.2Na/c5-1-9-3(7)11-4(8)10-2-6;;/q-2;2*+1
PDB
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Article
PubMed
9.50E+5n/an/an/an/an/an/an/an/a



Istituto di Bioscienze e Biorisorse, CNR, Via Pietro Castellino 81, Napoli, Italy.

Curated by ChEMBL


Assay Description
Inhibition of human CA2 after 15 mins by stopped-flow/Co2 hydration assay


Bioorg Med Chem 23: 4405-9 (2015)

More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (human))
BDBM50098589
PNG
(E285 | SODIUM TETRABORATE | Sodium tetraborate)
Show SMILES [O-]B(OB=O)OB([O-])OB=O
Show InChI InChI=1S/B4O7.2Na/c5-1-9-3(7)11-4(8)10-2-6;;/q-2;2*+1
PDB
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9.50E+5n/an/an/an/an/an/an/an/a



UniversitÓ degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Firenze), Italy.

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method


Bioorg Med Chem Lett 24: 4402-6 (2014)

More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (human))
BDBM50098589
PNG
(E285 | SODIUM TETRABORATE | Sodium tetraborate)
Show SMILES [O-]B(OB=O)OB([O-])OB=O
Show InChI InChI=1S/B4O7.2Na/c5-1-9-3(7)11-4(8)10-2-6;;/q-2;2*+1
PDB
MMDB

Reactome pathway
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UniChem

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PubMed
9.50E+5n/an/an/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase-2 by CO2 hydration reaction based colorimetric stopped-flow method


Citation and Details
More data for this
Ligand-Target Pair
Carbonic anhydrase


(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
BDBM50098589
PNG
(E285 | SODIUM TETRABORATE | Sodium tetraborate)
Show SMILES [O-]B(OB=O)OB([O-])OB=O
Show InChI InChI=1S/B4O7.2Na/c5-1-9-3(7)11-4(8)10-2-6;;/q-2;2*+1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

PubMed
9.10E+6n/an/an/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase-2 by CO2 hydration reaction based colorimetric stopped-flow method


Citation and Details
More data for this
Ligand-Target Pair