BDBM50099118 5-methyl-5-(4-phenoxyphenyl)barbituric acid::CHEMBL176467

SMILES CC1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=RTBMLCLTYAPKIF-UHFFFAOYSA-N

Data  3 KI  7 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50099118   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataKi:  52nMAssay Description:In vitro binding affinity against matrix metalloprotease 9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataKi:  65nMAssay Description:In vitro binding affinity against matrix metalloprotease 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataKi:  80nMAssay Description:In vitro binding affinity against matrix metalloprotease 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Stromelysin, matrix metalloproteinase-3More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataIC50:  81nMAssay Description:Inhibition of human neutrophil collagenase-I, Matrix metalloproteinase-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataIC50:  81nMAssay Description:Inhibition of Gelatinase A, matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataIC50:  65nMAssay Description:Inhibition of collagenase-3, Matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataIC50:  52nMAssay Description:Inhibition of Gelatinase B, matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of matrilysin, Matrix metalloproteinase-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed