BDBM50100674 CHEMBL541818::methyl 2-(4-aminophenyl)-4-(3,5-dimethoxy-4-methylphenyl)-1-oxo-7-(2-pyridylmethoxy)-1,2-dihydro-3-isoquinolinecarboxylate.dihydrochloride

SMILES COC(=O)c1c(-c2cc(OC)c(C)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1

InChI Key InChIKey=IEXOQDWHLPVRNW-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50100674   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50100674(CHEMBL541818 | methyl 2-(4-aminophenyl)-4-(3,5-dim...)
Affinity DataEC50:  37nMAssay Description:Relaxant effect on isolated rabbit corpus cavernosumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Canis lupus familiaris)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50100674(CHEMBL541818 | methyl 2-(4-aminophenyl)-4-(3,5-dim...)
Affinity DataIC50:  0.390nMAssay Description:Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Bos taurus)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50100674(CHEMBL541818 | methyl 2-(4-aminophenyl)-4-(3,5-dim...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of bovine adrenal gland Phosphodiesterase 2 (PDE2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50100674(CHEMBL541818 | methyl 2-(4-aminophenyl)-4-(3,5-dim...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of canine lung Phosphodiesterase 4 (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50100674(CHEMBL541818 | methyl 2-(4-aminophenyl)-4-(3,5-dim...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against canine heart Phosphodiesterase 3 (PDE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50100674(CHEMBL541818 | methyl 2-(4-aminophenyl)-4-(3,5-dim...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory activity against rat heart Phosphodiesterase 1(PDE1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed