BDBM501010 7-((6- ((3aR,6aR)- hexahydro- pyrrolo[3,4- b]pyrrol- l(2H)-yl)-4- methoxypyridin- 2-yl)amino)- 4-(1-methyl- 1H-pyrrolo[2,3- b]pyridin-4- yl)-2,3- dihydro-1H- pyrrolo[3,4- c]pyridin-1- one::US11021481, Compound I-682::US11078201, Compound I-682::US11548890, Compound I-682

SMILES COc1cc(Nc2cnc(c3CNC(=O)c23)-c2ccnc3n(C)ccc23)nc(c1)N1CC[C@@H]2CNC[C@H]12

InChI Key InChIKey=SWYXSKJJQYPMEJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 501010   

LigandPNGBDBM501010(7-((6- ((3aR,6aR)- hexahydro- pyrrolo[3,4- b]pyrro...)
Affinity DataIC50: 300nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM501010(7-((6- ((3aR,6aR)- hexahydro- pyrrolo[3,4- b]pyrro...)
Affinity DataIC50: 550nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM501010(7-((6- ((3aR,6aR)- hexahydro- pyrrolo[3,4- b]pyrro...)
Affinity DataIC50: 550nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM501010(7-((6- ((3aR,6aR)- hexahydro- pyrrolo[3,4- b]pyrro...)
Affinity DataIC50: 550nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM501010(7-((6- ((3aR,6aR)- hexahydro- pyrrolo[3,4- b]pyrro...)
Affinity DataIC50: 550nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent