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BDBM50101522 CHEMBL76869::[(S)-2-((S)-2-Cyclohexyl-1-phenethylcarbamoyl-ethylcarbamoyl)-5-p-tolyl-pentyl]-phosphonic acid::[2-(2-Cyclohexyl-1-phenethylcarbamoyl-ethylcarbamoyl)-5-p-tolyl-pentyl]-phosphonic acid

SMILES: Cc1ccc(CCC[C@H](CP(O)(O)=O)C(=O)N[C@@H](CC2CCCCC2)C(=O)NCCc2ccccc2)cc1

InChI Key: InChIKey=PNOAVGXEWQIVLB-IZLXSDGUSA-N

Data: 9 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50101522   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
72 kDa type IV collagenase


(Homo sapiens (Human))
BDBM50101522
PNG
(CHEMBL76869 | [(S)-2-((S)-2-Cyclohexyl-1-phenethyl...)
Show SMILES Cc1ccc(CCC[C@H](CP(O)(O)=O)C(=O)N[C@@H](CC2CCCCC2)C(=O)NCCc2ccccc2)cc1
Show InChI InChI=1S/C30H43N2O5P/c1-23-15-17-25(18-16-23)13-8-14-27(22-38(35,36)37)29(33)32-28(21-26-11-6-3-7-12-26)30(34)31-20-19-24-9-4-2-5-10-24/h2,4-5,9-10,15-18,26-28H,3,6-8,11-14,19-22H2,1H3,(H,31,34)(H,32,33)(H2,35,36,37)/t27-,28+/m1/s1
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2.5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of the Gelatinase-A enzyme was determined from purified NSO cells.


Bioorg Med Chem Lett 4: 2747-2752 (1994)


Article DOI: 10.1016/S0960-894X(01)80588-6
BindingDB Entry DOI: 10.7270/Q2JH3M3P
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))
BDBM50101522
PNG
(CHEMBL76869 | [(S)-2-((S)-2-Cyclohexyl-1-phenethyl...)
Show SMILES Cc1ccc(CCC[C@H](CP(O)(O)=O)C(=O)N[C@@H](CC2CCCCC2)C(=O)NCCc2ccccc2)cc1
Show InChI InChI=1S/C30H43N2O5P/c1-23-15-17-25(18-16-23)13-8-14-27(22-38(35,36)37)29(33)32-28(21-26-11-6-3-7-12-26)30(34)31-20-19-24-9-4-2-5-10-24/h2,4-5,9-10,15-18,26-28H,3,6-8,11-14,19-22H2,1H3,(H,31,34)(H,32,33)(H2,35,36,37)/t27-,28+/m1/s1
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2.5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibitory constant against matrix metalloproteinase-2


J Med Chem 44: 2333-43 (2001)


Article DOI: 10.1021/jm001090l
BindingDB Entry DOI: 10.7270/Q2JH3KFR
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50101522
PNG
(CHEMBL76869 | [(S)-2-((S)-2-Cyclohexyl-1-phenethyl...)
Show SMILES Cc1ccc(CCC[C@H](CP(O)(O)=O)C(=O)N[C@@H](CC2CCCCC2)C(=O)NCCc2ccccc2)cc1
Show InChI InChI=1S/C30H43N2O5P/c1-23-15-17-25(18-16-23)13-8-14-27(22-38(35,36)37)29(33)32-28(21-26-11-6-3-7-12-26)30(34)31-20-19-24-9-4-2-5-10-24/h2,4-5,9-10,15-18,26-28H,3,6-8,11-14,19-22H2,1H3,(H,31,34)(H,32,33)(H2,35,36,37)/t27-,28+/m1/s1
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277n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of the Stromelysin enzyme was determined from purified NSO cells.


Bioorg Med Chem Lett 4: 2747-2752 (1994)


Article DOI: 10.1016/S0960-894X(01)80588-6
BindingDB Entry DOI: 10.7270/Q2JH3M3P
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50101522
PNG
(CHEMBL76869 | [(S)-2-((S)-2-Cyclohexyl-1-phenethyl...)
Show SMILES Cc1ccc(CCC[C@H](CP(O)(O)=O)C(=O)N[C@@H](CC2CCCCC2)C(=O)NCCc2ccccc2)cc1
Show InChI InChI=1S/C30H43N2O5P/c1-23-15-17-25(18-16-23)13-8-14-27(22-38(35,36)37)29(33)32-28(21-26-11-6-3-7-12-26)30(34)31-20-19-24-9-4-2-5-10-24/h2,4-5,9-10,15-18,26-28H,3,6-8,11-14,19-22H2,1H3,(H,31,34)(H,32,33)(H2,35,36,37)/t27-,28+/m1/s1
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277n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibitory constant against matrix metalloproteinase-3


J Med Chem 44: 2333-43 (2001)


Article DOI: 10.1021/jm001090l
BindingDB Entry DOI: 10.7270/Q2JH3KFR
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))
BDBM50101522
PNG
(CHEMBL76869 | [(S)-2-((S)-2-Cyclohexyl-1-phenethyl...)
Show SMILES Cc1ccc(CCC[C@H](CP(O)(O)=O)C(=O)N[C@@H](CC2CCCCC2)C(=O)NCCc2ccccc2)cc1
Show InChI InChI=1S/C30H43N2O5P/c1-23-15-17-25(18-16-23)13-8-14-27(22-38(35,36)37)29(33)32-28(21-26-11-6-3-7-12-26)30(34)31-20-19-24-9-4-2-5-10-24/h2,4-5,9-10,15-18,26-28H,3,6-8,11-14,19-22H2,1H3,(H,31,34)(H,32,33)(H2,35,36,37)/t27-,28+/m1/s1
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366n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of the Collagenase enzyme was determined from purified NSO cells.


Bioorg Med Chem Lett 4: 2747-2752 (1994)


Article DOI: 10.1016/S0960-894X(01)80588-6
BindingDB Entry DOI: 10.7270/Q2JH3M3P
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM50101522
PNG
(CHEMBL76869 | [(S)-2-((S)-2-Cyclohexyl-1-phenethyl...)
Show SMILES Cc1ccc(CCC[C@H](CP(O)(O)=O)C(=O)N[C@@H](CC2CCCCC2)C(=O)NCCc2ccccc2)cc1
Show InChI InChI=1S/C30H43N2O5P/c1-23-15-17-25(18-16-23)13-8-14-27(22-38(35,36)37)29(33)32-28(21-26-11-6-3-7-12-26)30(34)31-20-19-24-9-4-2-5-10-24/h2,4-5,9-10,15-18,26-28H,3,6-8,11-14,19-22H2,1H3,(H,31,34)(H,32,33)(H2,35,36,37)/t27-,28+/m1/s1
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1.70E+3n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibitory constant against matrix metalloproteinase-1


J Med Chem 44: 2333-43 (2001)


Article DOI: 10.1021/jm001090l
BindingDB Entry DOI: 10.7270/Q2JH3KFR
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM50101522
PNG
(CHEMBL76869 | [(S)-2-((S)-2-Cyclohexyl-1-phenethyl...)
Show SMILES Cc1ccc(CCC[C@H](CP(O)(O)=O)C(=O)N[C@@H](CC2CCCCC2)C(=O)NCCc2ccccc2)cc1
Show InChI InChI=1S/C30H43N2O5P/c1-23-15-17-25(18-16-23)13-8-14-27(22-38(35,36)37)29(33)32-28(21-26-11-6-3-7-12-26)30(34)31-20-19-24-9-4-2-5-10-24/h2,4-5,9-10,15-18,26-28H,3,6-8,11-14,19-22H2,1H3,(H,31,34)(H,32,33)(H2,35,36,37)/t27-,28+/m1/s1
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1.70E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of the Stromelysin enzyme was determined from purified NSO cells.


Bioorg Med Chem Lett 4: 2747-2752 (1994)


Article DOI: 10.1016/S0960-894X(01)80588-6
BindingDB Entry DOI: 10.7270/Q2JH3M3P
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50101522
PNG
(CHEMBL76869 | [(S)-2-((S)-2-Cyclohexyl-1-phenethyl...)
Show SMILES Cc1ccc(CCC[C@H](CP(O)(O)=O)C(=O)N[C@@H](CC2CCCCC2)C(=O)NCCc2ccccc2)cc1
Show InChI InChI=1S/C30H43N2O5P/c1-23-15-17-25(18-16-23)13-8-14-27(22-38(35,36)37)29(33)32-28(21-26-11-6-3-7-12-26)30(34)31-20-19-24-9-4-2-5-10-24/h2,4-5,9-10,15-18,26-28H,3,6-8,11-14,19-22H2,1H3,(H,31,34)(H,32,33)(H2,35,36,37)/t27-,28+/m1/s1
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2.12E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of the Gelatinase-A enzyme was determined from purified NSO cells.


Bioorg Med Chem Lett 4: 2747-2752 (1994)


Article DOI: 10.1016/S0960-894X(01)80588-6
BindingDB Entry DOI: 10.7270/Q2JH3M3P
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM50101522
PNG
(CHEMBL76869 | [(S)-2-((S)-2-Cyclohexyl-1-phenethyl...)
Show SMILES Cc1ccc(CCC[C@H](CP(O)(O)=O)C(=O)N[C@@H](CC2CCCCC2)C(=O)NCCc2ccccc2)cc1
Show InChI InChI=1S/C30H43N2O5P/c1-23-15-17-25(18-16-23)13-8-14-27(22-38(35,36)37)29(33)32-28(21-26-11-6-3-7-12-26)30(34)31-20-19-24-9-4-2-5-10-24/h2,4-5,9-10,15-18,26-28H,3,6-8,11-14,19-22H2,1H3,(H,31,34)(H,32,33)(H2,35,36,37)/t27-,28+/m1/s1
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1.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of the Collagenase enzyme was determined from purified NSO cells.


Bioorg Med Chem Lett 4: 2747-2752 (1994)


Article DOI: 10.1016/S0960-894X(01)80588-6
BindingDB Entry DOI: 10.7270/Q2JH3M3P
More data for this
Ligand-Target Pair