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BDBM50101680 CHEMBL3394918

SMILES: O=C(N\N=C\c1cccnc1)c1ccc(NC(=O)c2ccccc2)cc1

InChI Key: InChIKey=JURYGZJGNNQDQE-HYARGMPZSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50101680   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone chaperone ASF1A


(Homo sapiens)
BDBM50101680
PNG
(CHEMBL3394918)
Show SMILES O=C(N\N=C\c1cccnc1)c1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C20H16N4O2/c25-19(16-6-2-1-3-7-16)23-18-10-8-17(9-11-18)20(26)24-22-14-15-5-4-12-21-13-15/h1-14H,(H,23,25)(H,24,26)/b22-14+
PDB

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PC cid
PC sid
UniChem

Patents


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Article
PubMed
n/an/a 8.50E+4n/an/an/an/an/an/a



Colorado Center for Drug Discovery, Colorado State University, Department of Chemistry, Fort Collins, CO 80523-1872, USA. Electronic address: Greg.Miknis@Colostate.edu.

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human Asf1a binding with H3/H4 assessed as fluorescence intensity after 30 mins by ALPHA assay


Bioorg Med Chem Lett 25: 963-8 (2015)

More data for this
Ligand-Target Pair