BDBM50103634 CL-287389::FK-235::Nilvadipine::Nivadipine::SK&F-102362

SMILES COC(=O)C1=C(NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC(C)C)C#N

InChI Key InChIKey=FAIIFDPAEUKBEP-UHFFFAOYSA-N

Data  3 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50103634   

TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
National Institutes Of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM50103634(CL-287389 | FK-235 | Nilvadipine | Nivadipine | SK...)
Affinity DataEC50:  2.00E+3nMAssay Description:Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Rattus norvegicus)
National Institutes Of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM50103634(CL-287389 | FK-235 | Nilvadipine | Nivadipine | SK...)
Affinity DataEC50:  1.05E+4nMAssay Description:Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
National Institutes Of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM50103634(CL-287389 | FK-235 | Nilvadipine | Nivadipine | SK...)
Affinity DataEC50:  1.90E+3nMAssay Description:Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50103634(CL-287389 | FK-235 | Nilvadipine | Nivadipine | SK...)
Affinity DataIC50:  1.80E+4nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 0.1 uM) in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
National Institutes Of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM50103634(CL-287389 | FK-235 | Nilvadipine | Nivadipine | SK...)
Affinity DataEC50:  890nMAssay Description:Competitive binding affinity to human PXR LBD (111 to 434) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Rattus norvegicus)
Suntory Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50103634(CL-287389 | FK-235 | Nilvadipine | Nivadipine | SK...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channels of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103634(CL-287389 | FK-235 | Nilvadipine | Nivadipine | SK...)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
National Institutes Of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM50103634(CL-287389 | FK-235 | Nilvadipine | Nivadipine | SK...)
Affinity DataEC50:  1.40E+3nMAssay Description:Activation of PXR in human cryopreserved hepatocytes assessed as induction of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed