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BDBM50104353 4-[2,5-Bis-(4-chloro-phenyl)-3H-imidazol-4-yl]-pyridine::CHEMBL85009

SMILES: Clc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(Cl)cc1)-c1ccncc1

InChI Key: InChIKey=AWHRFPLTQPNOTD-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50104353   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucagon receptor


(Homo sapiens (Human))
BDBM50104353
PNG
(4-[2,5-Bis-(4-chloro-phenyl)-3H-imidazol-4-yl]-pyr...)
Show SMILES Clc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(Cl)cc1)-c1ccncc1
Show InChI InChI=1S/C20H13Cl2N3/c21-16-5-1-13(2-6-16)18-19(14-9-11-23-12-10-14)25-20(24-18)15-3-7-17(22)8-4-15/h1-12H,(H,24,25)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.20E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Affinity for human glucagon receptor in presence of Mg2+


Bioorg Med Chem Lett 11: 2549-53 (2001)


Article DOI: 10.1016/s0960-894x(01)00498-x
BindingDB Entry DOI: 10.7270/Q2FB527Z
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104353
PNG
(4-[2,5-Bis-(4-chloro-phenyl)-3H-imidazol-4-yl]-pyr...)
Show SMILES Clc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(Cl)cc1)-c1ccncc1
Show InChI InChI=1S/C20H13Cl2N3/c21-16-5-1-13(2-6-16)18-19(14-9-11-23-12-10-14)25-20(24-18)15-3-7-17(22)8-4-15/h1-12H,(H,24,25)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 190n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human glucagon receptor in absence of Mg2+ expressed as IC50


Bioorg Med Chem Lett 11: 2549-53 (2001)


Article DOI: 10.1016/s0960-894x(01)00498-x
BindingDB Entry DOI: 10.7270/Q2FB527Z
More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (Human))
BDBM50104353
PNG
(4-[2,5-Bis-(4-chloro-phenyl)-3H-imidazol-4-yl]-pyr...)
Show SMILES Clc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(Cl)cc1)-c1ccncc1
Show InChI InChI=1S/C20H13Cl2N3/c21-16-5-1-13(2-6-16)18-19(14-9-11-23-12-10-14)25-20(24-18)15-3-7-17(22)8-4-15/h1-12H,(H,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Affinity for human glucagon receptor in presence of Mg2+


Bioorg Med Chem Lett 11: 2549-53 (2001)


Article DOI: 10.1016/s0960-894x(01)00498-x
BindingDB Entry DOI: 10.7270/Q2FB527Z
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104353
PNG
(4-[2,5-Bis-(4-chloro-phenyl)-3H-imidazol-4-yl]-pyr...)
Show SMILES Clc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(Cl)cc1)-c1ccncc1
Show InChI InChI=1S/C20H13Cl2N3/c21-16-5-1-13(2-6-16)18-19(14-9-11-23-12-10-14)25-20(24-18)15-3-7-17(22)8-4-15/h1-12H,(H,24,25)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
n/an/a 23n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human glucagon receptor expressed in CHO cell membranes by radioligand displacement assay


Citation and Details

Article DOI: 10.1007/s00044-013-0869-9
BindingDB Entry DOI: 10.7270/Q23R0V9H
More data for this
Ligand-Target Pair