BDBM50105015 4-(4-tert-Butyl-pyrimidin-1-yl)-N-(2-hydroxy-ethoxy)-3-(3-methoxy-phenoxy)-benzenesulfonamide::4-tert-Butyl-N-[6-(2-hydroxy-ethoxy)-5-(3-methoxy-phenoxy)-pyrimidin-4-yl]-benzenesulfonamide::CHEMBL115951::Ro-46-2005

SMILES COc1cccc(Oc2c(NS(=O)(=O)c3ccc(cc3)C(C)(C)C)ncnc2OCCO)c1

InChI Key InChIKey=ZNXOKLWCOWOECF-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50105015   

TargetEndothelin-1 receptor(Pig)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105015(4-(4-tert-Butyl-pyrimidin-1-yl)-N-(2-hydroxy-ethox...)
Affinity DataIC50: 160nMAssay Description:In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105015(4-(4-tert-Butyl-pyrimidin-1-yl)-N-(2-hydroxy-ethox...)
Affinity DataIC50: 220nMAssay Description:Displacement of 125I-ET1 from human smooth muscle ETA receptor expressed in fall armyworm sf9 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105015(4-(4-tert-Butyl-pyrimidin-1-yl)-N-(2-hydroxy-ethox...)
Affinity DataIC50: 220nMAssay Description:Displacement of 125I-ET1 from human smooth muscle ETA receptor expressed in fall armyworm sf9 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105015(4-(4-tert-Butyl-pyrimidin-1-yl)-N-(2-hydroxy-ethox...)
Affinity DataIC50: 230nMAssay Description:In vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Rat)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105015(4-(4-tert-Butyl-pyrimidin-1-yl)-N-(2-hydroxy-ethox...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of 125I-ET1 from rat aortic ring ETB receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin receptor type B(Rat)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105015(4-(4-tert-Butyl-pyrimidin-1-yl)-N-(2-hydroxy-ethox...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of 125I-ET1 from rat aortic ring ETB receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105015(4-(4-tert-Butyl-pyrimidin-1-yl)-N-(2-hydroxy-ethox...)
Affinity DataIC50: 1.10E+3nMAssay Description:Ability to inhibit specific binding of [125I]- -ET-1 to human GH cells which express endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed