BDBM50105103 1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1-yl}-3-(4-fluoro-phenyl)-propan-1-one::CHEMBL116735

SMILES Fc1ccc(CCC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1

InChI Key InChIKey=MUAYITOFLINYIL-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50105103   

TargetDelta-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105103(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  9.38E+3nMAssay Description:Inhibition of ligand binding to human delta opioid receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1B) dopamine receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105103(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  3.02E+3nMAssay Description:Inhibition of human dopamine receptor D5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105103(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  4.30E+3nMAssay Description:Binding affinity against L-type calcium channel verapamil siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105103(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  977nMAssay Description:Inhibition of human dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105103(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  2.82E+3nMAssay Description:Binding affinity against opioid receptor kappa 1 by using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105103(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of human 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105103(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  5.08E+3nMAssay Description:Inhibition of human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105103(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  1.66E+3nMAssay Description:Inhibition of histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105103(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  1.35E+3nMAssay Description:Inhibition of human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105103(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  3.66E+3nMAssay Description:Binding affinity against mu opiate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105103(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  1.28E+3nMAssay Description:Binding affinity against dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105103(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  716nMAssay Description:Inhibition of human dopamine receptor D4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105103(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibition of human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105103(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of human 5-hydroxytryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105103(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  1.34E+3nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105103(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed