BDBM50105680 3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-2-methyl-propionamide::CHEMBL97108::N-hydroxy-2-methyl-3-(4-(phenylsulfonamido)phenyl)propanamide::US8796330, 92

SMILES CC(Cc1ccc(NS(=O)(=O)c2ccccc2)cc1)C(=O)NO

InChI Key InChIKey=RKDXFSHFQNWESJ-UHFFFAOYSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50105680   

TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

US Patent
LigandPNGBDBM50105680(3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-2-meth...)
Affinity DataIC50:  1.70E+4nMT: 2°CAssay Description:For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

US Patent
LigandPNGBDBM50105680(3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-2-meth...)
Affinity DataIC50:  1.70E+4nMAssay Description:In vitro inhibition of partially purified recombinant human Histone deacetylase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

US Patent
LigandPNGBDBM50105680(3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-2-meth...)
Affinity DataEC50: >2.50E+4nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Aton Pharma

Curated by ChEMBL
LigandPNGBDBM50105680(3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-2-meth...)
Affinity DataEC50: >2.50E+4nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

US Patent
LigandPNGBDBM50105680(3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-2-meth...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibitory concentration against human Histone deacetylase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed