BDBM50105696 (E)-3-[4-(3,4-Dichloro-benzenesulfonylamino)-phenyl]-N-hydroxy-acrylamide::3-(4-(3,4-dichlorophenylsulfonamido)phenyl)-N-hydroxyacrylamide::CHEMBL95850::US8796330, 109

SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1

InChI Key InChIKey=WAJRLVVOBKIZMX-FPYGCLRLSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50105696   

TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

US Patent
LigandPNGBDBM50105696((E)-3-[4-(3,4-Dichloro-benzenesulfonylamino)-pheny...)
Affinity DataIC50:  120nMT: 2°CAssay Description:For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))TBA
LigandPNGBDBM50105696((E)-3-[4-(3,4-Dichloro-benzenesulfonylamino)-pheny...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Homo sapiens (human) HDAC8More data for this Ligand-Target Pair
In DepthDetails Article
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

US Patent
LigandPNGBDBM50105696((E)-3-[4-(3,4-Dichloro-benzenesulfonylamino)-pheny...)
Affinity DataIC50:  100nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

US Patent
LigandPNGBDBM50105696((E)-3-[4-(3,4-Dichloro-benzenesulfonylamino)-pheny...)
Affinity DataEC50:  5.00E+3nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed