BDBM50105753 4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-imidazol-1-yl]-piperidine-1-carboxylic acid ethyl ester::CHEMBL95931::D3RKN_45

SMILES CCOC(=O)N1CCC(CC1)n1cnc(c1-c1ccnc(N)n1)-c1ccc(F)cc1

InChI Key InChIKey=WNZMTWAJENZPDM-UHFFFAOYSA-N

Data  1 IC50  9 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50105753   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105753(4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-...)
Affinity DataIC50:  33nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50105753(4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2021More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50105753(4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-...)
Affinity DataKd:  7.80E+3nMAssay Description:D3R2022More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50105753(4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2025More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50105753(4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2026More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50105753(4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2026More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50105753(4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2026More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50105753(4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-...)
Affinity DataKd:  2.20E+3nMAssay Description:D3R2026More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50105753(4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-...)
Affinity DataKd:  5.40E+3nMAssay Description:D3R2026More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50105753(4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-...)
Affinity DataKd:  4.80E+3nMAssay Description:D3R2026More data for this Ligand-Target Pair
In DepthDetails PubMed