BDBM50106249 CHEMBL92139::[2-(1-Benzenesulfonyl-1H-indol-4-yl)-ethyl]-dimethyl-amine

SMILES CN(C)CCc1cccc2n(ccc12)S(=O)(=O)c1ccccc1

InChI Key InChIKey=GIHFRARKMBMXPG-UHFFFAOYSA-N

Data  14 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50106249   

Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50106249(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor transfected in HeLa cells after 60 mins by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50106249(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Affinity DataKi:  1.5nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50106249(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity as displacement of [3H]-5-HT binding to 5-hydroxytryptamine 6 receptor in HeLa cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50106249(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50106249(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]-5-HT radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50106249(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Affinity DataKi:  9.30nMAssay Description:Binding affinity against 5-hydroxytryptamine 1D receptor in CHO cells using [3H]-5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50106249(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Affinity DataKi:  11nMAssay Description:Binding affinity against 5-hydroxytryptamine 1B receptor in CHO cells using [3H]-5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50106249(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Affinity DataKi:  18nMAssay Description:Binding affinity for 5-hydroxytryptamine 2 receptor of rat cortical membrane using [3H]-DOB radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50106249(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Affinity DataKi:  170nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor in HeLa cells was determined using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50106249(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Affinity DataKi:  300nMAssay Description:Binding affinity against dopamine receptor D3 in HEK 293 cells using [3H]-spiperone radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50106249(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Affinity DataKi:  460nMAssay Description:Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50106249(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Affinity DataKi:  1.60E+3nMAssay Description:Binding affinity against dopamine receptor D2 using [3H]-spiperone radioligand in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50106249(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Affinity DataKi: >3.20E+3nMAssay Description:Binding affinity against dopamine receptor D4 cloned in HEK 293 cells using [3H]-spiperone radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 5A(RAT)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50106249(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Affinity DataKi:  3.40E+3nMAssay Description:Binding affinity against 5-hydroxytryptamine 5A receptor in HEK 293 cells was determined using [3H]-LSD as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed