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BDBM50107803 6-Methyl-4'-trifluoromethyl-biphenyl-2-carboxylic acid [7-(thiophene-2-sulfonylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl]-amide::CHEMBL142272

SMILES: Cc1cccc(C(=O)Nc2ccc3CCC(CCc3c2)NS(=O)(=O)c2cccs2)c1-c1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=MLJWCPIALKPLOS-UHFFFAOYNA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50107803   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Microsomal triglyceride transfer protein


(Homo sapiens (Human))
BDBM50107803
PNG
(6-Methyl-4'-trifluoromethyl-biphenyl-2-carboxylic ...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3CCC(CCc3c2)NS(=O)(=O)c2cccs2)c1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1/C30H27F3N2O3S2/c1-19-4-2-5-26(28(19)21-7-12-23(13-8-21)30(31,32)33)29(36)34-25-16-10-20-9-14-24(15-11-22(20)18-25)35-40(37,38)27-6-3-17-39-27/h2-8,10,12-13,16-18,24,35H,9,11,14-15H2,1H3,(H,34,36)
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PC cid
PC sid
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Patents


Similars

Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against MTP using MTP transfer assay


J Med Chem 44: 4677-87 (2001)


Article DOI: 10.1021/jm010294e
BindingDB Entry DOI: 10.7270/Q23F4NXH
More data for this
Ligand-Target Pair
Apolipoprotein B-100


(Homo sapiens (Human))
BDBM50107803
PNG
(6-Methyl-4'-trifluoromethyl-biphenyl-2-carboxylic ...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3CCC(CCc3c2)NS(=O)(=O)c2cccs2)c1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1/C30H27F3N2O3S2/c1-19-4-2-5-26(28(19)21-7-12-23(13-8-21)30(31,32)33)29(36)34-25-16-10-20-9-14-24(15-11-22(20)18-25)35-40(37,38)27-6-3-17-39-27/h2-8,10,12-13,16-18,24,35H,9,11,14-15H2,1H3,(H,34,36)
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UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.60n/an/an/an/an/an/a



Novartis Institute for Biomedical Reasearch

Curated by ChEMBL


Assay Description
Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nM


J Med Chem 44: 4677-87 (2001)


Article DOI: 10.1021/jm010294e
BindingDB Entry DOI: 10.7270/Q23F4NXH
More data for this
Ligand-Target Pair