BDBM50107843 (-)-FTC::524W91::BW-524W91::CHEBI:31536::Emtricitabine::Emtriva::FTC::FTC-(-)

SMILES Nc1nc(=O)n(cc1F)[C@@H]1CS[C@H](CO)O1

InChI Key InChIKey=XQSPYNMVSIKCOC-NTSWFWBYSA-N

Data  4 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50107843   

TargetAlbumin(Homo sapiens (Human))
Mercer University

Curated by ChEMBL
LigandPNGBDBM50107843((-)-FTC | 524W91 | BW-524W91 | CHEBI:31536 | Emtri...)
Affinity DataKd:  4.40E+4nMAssay Description:Binding affinity to human serum albumin with excitation at 280 nm after 2 hrs by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50107843((-)-FTC | 524W91 | BW-524W91 | CHEBI:31536 | Emtri...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50107843((-)-FTC | 524W91 | BW-524W91 | CHEBI:31536 | Emtri...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50107843((-)-FTC | 524W91 | BW-524W91 | CHEBI:31536 | Emtri...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50107843((-)-FTC | 524W91 | BW-524W91 | CHEBI:31536 | Emtri...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed