BDBM50108686 1-[6-fluorospiro[3,4-dihydro-2H-chromene-2,4'-(hexahydropyridine)]-1-yl]-4-phenyl-2-butanol::CHEMBL149510

SMILES OC(CCc1ccccc1)CN1CCC2(CC1)CCc1cc(F)ccc1O2

InChI Key InChIKey=JPTJNKGXZCFAFQ-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50108686   

Target5-hydroxytryptamine receptor 2A(Rat)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50108686(1-[6-fluorospiro[3,4-dihydro-2H-chromene-2,4'-(hex...)
Affinity DataKi:  29nMAssay Description:Binding affinity for displacement of [3H]ketanserin to rat 5-hydroxytryptamine 2A receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50108686(1-[6-fluorospiro[3,4-dihydro-2H-chromene-2,4'-(hex...)
Affinity DataKi:  31nMAssay Description:Binding affinity for displacement of [3H]ketanserin to human 5-hydroxytryptamine 2A receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50108686(1-[6-fluorospiro[3,4-dihydro-2H-chromene-2,4'-(hex...)
Affinity DataKi:  1.10E+3nMAssay Description:Binding affinity for displacement of [3H]spiperone to human dopamine D2 (hD2) receptors stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50108686(1-[6-fluorospiro[3,4-dihydro-2H-chromene-2,4'-(hex...)
Affinity DataKi:  1.50E+3nMAssay Description:Binding affinity for displacement of [3H]mesulergine to human 5-hydroxytryptamine 2C receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed