BDBM50108711 4-[[1-(2-(2,4-Difluorophenyl)ethyl)-4-piperidinyl]sulfonyl]benzonitrile::4-{1-[2-(2,4-Difluoro-phenyl)-ethyl]-piperidine-4-sulfonyl}-benzonitrile::CHEMBL150220

SMILES Fc1ccc(CCN2CCC(CC2)S(=O)(=O)c2ccc(cc2)C#N)c(F)c1

InChI Key InChIKey=DQDFRZYUWQHTEY-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50108711   

Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50108711(4-[[1-(2-(2,4-Difluorophenyl)ethyl)-4-piperidinyl]...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity for displacement of [3H]ketanserin to rat 5-hydroxytryptamine 2A receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50108711(4-[[1-(2-(2,4-Difluorophenyl)ethyl)-4-piperidinyl]...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity for displacement of [3H]ketanserin to human 5-hydroxytryptamine 2A receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50108711(4-[[1-(2-(2,4-Difluorophenyl)ethyl)-4-piperidinyl]...)
Affinity DataKi:  560nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50108711(4-[[1-(2-(2,4-Difluorophenyl)ethyl)-4-piperidinyl]...)
Affinity DataKi:  560nMAssay Description:Displacement of [3H]-dofetilide to HEK cells stably expressing hERG voltage-gated IKr potassium channel Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50108711(4-[[1-(2-(2,4-Difluorophenyl)ethyl)-4-piperidinyl]...)
Affinity DataKi:  640nMAssay Description:Binding affinity for displacement of [3H]mesulergine to human 5-hydroxytryptamine 2C receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50108711(4-[[1-(2-(2,4-Difluorophenyl)ethyl)-4-piperidinyl]...)
Affinity DataKi: >1.50E+3nMAssay Description:Binding affinity for displacement of [3H]spiperone to human dopamine D2 (hD2) receptors stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed