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BDBM50109577 CHEMBL3604155

SMILES: Fc1ccc(NC(=O)c2n[nH]cc2Br)c(Cl)c1

InChI Key: InChIKey=WDEPOKCKOUIAMH-UHFFFAOYSA-N

Data: 2 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50109577   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109577
PNG
(CHEMBL3604155)
Show SMILES Fc1ccc(NC(=O)c2n[nH]cc2Br)c(Cl)c1
Show InChI InChI=1S/C10H6BrClFN3O/c11-6-4-14-16-9(6)10(17)15-8-2-1-5(13)3-7(8)12/h1-4H,(H,14,16)(H,15,17)
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 39n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109577
PNG
(CHEMBL3604155)
Show SMILES Fc1ccc(NC(=O)c2n[nH]cc2Br)c(Cl)c1
Show InChI InChI=1S/C10H6BrClFN3O/c11-6-4-14-16-9(6)10(17)15-8-2-1-5(13)3-7(8)12/h1-4H,(H,14,16)(H,15,17)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 290n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair