BDBM50109794 3-(2-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-ethyl)-2-(4-dimethylamino-phenyl)-3H-quinazolin-4-one::CHEMBL157162

SMILES COc1ccc(CCN(C)CCn2c(nc3ccccc3c2=O)-c2ccc(cc2)N(C)C)cc1OC

InChI Key InChIKey=IERNEONMXXBPJS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50109794   

TargetATP-dependent translocase ABCB1(Mus musculus)
Xenova

Curated by ChEMBL
LigandPNGBDBM50109794(3-(2-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amin...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibitory activity against P-glyco-protein (Pgp) using accumulation assay for Pgp expressing EMT6/AR1.0 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50109794(3-(2-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amin...)
Affinity DataIC50:  3.70E+4nMAssay Description:Inhibition of multidrug resistance associated protein type 1 (MRP1) assayed by an accumulation assay in COR.L23/R cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed