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BDBM50109847 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(4-fluoro-phenyl)-N'-cyano-piperidine-1-carboxamidine::CHEMBL347798

SMILES: Fc1ccc(-[#7]-[#6](=[#7]C#N)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2\c3ccc(Cl)cc3-[#6]-[#6]-c3cc(Br)cnc-23)cc1

InChI Key: InChIKey=BNESXHDPUFELSD-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50109847   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50109847
PNG
(4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohep...)
Show SMILES Fc1ccc(NC(=NC#N)N2CCC(CC2)=C2c3ccc(Cl)cc3CCc3cc(Br)cnc23)cc1
Show InChI InChI=1S/C27H22BrClFN5/c28-20-13-19-2-1-18-14-21(29)3-8-24(18)25(26(19)32-15-20)17-9-11-35(12-10-17)27(33-16-31)34-23-6-4-22(30)5-7-23/h3-8,13-15H,1-2,9-12H2,(H,33,34)
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MMDB

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Similars

Article
PubMed
n/an/a 38n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
FPT inhibitory activity was determined by the ability of the compound to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-ras-C...


Bioorg Med Chem Lett 12: 601-5 (2002)


Article DOI: 10.1016/s0960-894x(01)00826-5
BindingDB Entry DOI: 10.7270/Q2FF3RPB
More data for this
Ligand-Target Pair