BDBM50110183 Abemaciclib::LY-2835219::US10626107, Example LY2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib

SMILES: CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1

InChI Key: InChIKey=UZWDCWONPYILKI-UHFFFAOYSA-N

Data: 11 KI  131 IC50  3 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 219 hits for monomerid = 50110183   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Replicase polyprotein 1ab (2019-nCoV)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.62E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.51	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	52.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	263	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	81.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 7 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	667	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 9 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	34.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 1 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.51	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	52.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	263	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	81.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 7 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	667	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 9 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	34.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G1/S-specific cyclin- 2 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	319	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.81	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G1/S-specific cyclin- 2 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	319	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.81	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G1/S-specific cyclin-D3 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.08	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G1/S-specific cyclin- 2 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	319	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.81	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G1/S-specific cyclin-D3 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.08	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.92	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G1/S-specific cyclin- 2 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	319	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	769	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-E1 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.81	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G1/S-specific cyclin-D3 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.08	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.92	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/6 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/6 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B (Spiny starfish)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	308	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	111	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.41	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	306	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	192	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.41	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	306	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 (Human)	BDBM50110183 (Abemaciclib | LY-2835219 | US10696678, Example LY2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	192	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair