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BDBM50111284 8-{4-[(4-Hydroxy-2-oxo-7-trifluoromethyl-1,2-dihydro-quinoline-3-carbonyl)-amino]-phenoxy}-octanoic acid::CHEMBL10614

SMILES: OC(=O)CCCCCCCOc1ccc(NC(=O)c2c(O)c3ccc(cc3[nH]c2=O)C(F)(F)F)cc1

InChI Key: InChIKey=YHDUPJANYHVWAA-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50111284   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Plasminogen activator inhibitor-1


(Homo sapiens (Human))
BDBM50111284
PNG
(8-{4-[(4-Hydroxy-2-oxo-7-trifluoromethyl-1,2-dihyd...)
Show SMILES OC(=O)CCCCCCCOc1ccc(NC(=O)c2c(O)c3ccc(cc3[nH]c2=O)C(F)(F)F)cc1
Show InChI InChI=1S/C25H25F3N2O6/c26-25(27,28)15-7-12-18-19(14-15)30-24(35)21(22(18)33)23(34)29-16-8-10-17(11-9-16)36-13-5-3-1-2-4-6-20(31)32/h7-12,14H,1-6,13H2,(H,29,34)(H,31,32)(H2,30,33,35)
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Similars

Article
PubMed
n/an/a 1.03E+3n/an/an/an/an/an/a



Xenova Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.


Bioorg Med Chem Lett 12: 1063-6 (2002)


Article DOI: 10.1016/s0960-894x(02)00078-1
BindingDB Entry DOI: 10.7270/Q2W958HQ
More data for this
Ligand-Target Pair