BDBM50112494 7-{5-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-2-methyl-4-nitro-benzoimidazol-1-ylmethyl}-naphthalene-2-carboxamidine::CHEMBL25351

SMILES CC([NH-])=[N+]1CCC(CC1)Oc1ccc2n(Cc3ccc4ccc(cc4c3)C(N)=N)c(C)nc2c1[N+]([O-])=O

InChI Key InChIKey=AMHANGMCUDSEIH-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50112494   

TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50112494(7-{5-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-2-methy...)
Affinity DataKi:  0.300nMAssay Description:Competitive inhibition of coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50112494(7-{5-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-2-methy...)
Affinity DataKi:  0.300nMAssay Description:Tested in vitro for the inhibitory potency against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50112494(7-{5-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-2-methy...)
Affinity DataKi:  3nMAssay Description:Tested in vitro for the selectivity against trypsin (Trp)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50112494(7-{5-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-2-methy...)
Affinity DataKi:  3nMAssay Description:Competitive inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50112494(7-{5-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-2-methy...)
Affinity DataKi: >5.00E+3nMAssay Description:Tested in vitro for the selectivity against thrombin (IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50112494(7-{5-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-2-methy...)
Affinity DataKi:  5.00E+3nMAssay Description:Competitive inhibition of coagulation factor IIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed